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Access of the Substrate to the Active Site of Yeast Oxidosqualene Cyclase: An Inhibition and Site-Directed Mutagenesis Approach

✍ Scribed by Simonetta Oliaro-Bosso; Tanja Schulz-Gasch; Gianni Balliano; Franca Viola

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
356 KB
Volume
6
Category
Article
ISSN
1439-4227

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## Abstract Histamine H~1~ antagonists or “antihistamines” are one of the most prescribed drug families in Western countries. They exert their effect by binding to the histamine H~1~ receptor, a receptor belonging to the class of rhodopsin‐like G protein‐coupled receptors (GPCRs). In this review, t