Access of soluble antigens to the endoplasmic reticulum can explain cross-presentation by dendritic cells

Increased expression of HSP70 by colon c

Increased expression of HSP70 by colon cancer cells is not always associated with access to the dendritic cell cross-presentation pathway

✍ Lina Matera; Sarah Forno; Alessandra Galetto; Francesco Moro; Stefano Garetto; A 📂 Article 📅 2007 🏛 SP Versita 🌐 English ⚖ 507 KB

## Abstract Dendritic cells (DCs) are highly specialized antigen-presenting cells endowed with the unique ability to not only present exogenous antigens upon exposure to MHC II, but also to cross-present these upon exposure to MHC I. This property was exploited to generate the tumor-specific CD8 cy