Acceleration of proliferative activity of esophageal squamous cell carcinoma with invasion beyond the mucosa: Immunohistochemical analysis of Ki-67 and p53 antigen in relation to histopathologic findings
✍ Scribed by Tohru Kawamura; Narihide Goseki; Morio Koike; Touichiro Takizawa; Mitsuo Endo
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 634 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
BACKGROUND.
The authors observed patients with superficial esophageal squamous cell carcinoma (s-ESC). Those with cancer invasion beyond the muscularis mucosae (SM-carcinoma) had an extremely poor prognosis, compared with those with intramucosal carcinoma (M-carcinoma). Therefore, we surveyed cell proliferative activities in relation to pathologic findings of the s-ESC. METHODS. p53 protein expression and Ki-67 labeling index (LI) were surveyed with detailed pathologic examinations of 75 s-ESC lesions from 70 patients who underwent esophagectomy. The results were compared by statistical analysis using the chi-square test and unpaired Student's t-test. RESULTS. p53 protein expression was observed in 57.3% of the patients with s-ESC. The frequency and intensity of its accumulation correlated with the depth of cancer invasion and was markedly elevated in invasion beyond the muscularis mucosae. The LI of Ki-67 positive nuclei was also increased with cancer invasion.
The values in the intraepithelial carcinoma and in carcinoma with invasion to the muscularis mucosae were 48.5 ? 13.7% [mean t standard deviation (SD)] and 66.6 t 12.9%, respectively, and the difference is significant, P < 0.01. In the SMcarcinomas, the Lis of Ki-67, with or without lymph node metastasis, were 73.5 2 10.0% and 64.4 2 11.3%, respectively, and the former was higher than the latter with a significant difference, P < 0.05.
CONCLUSIONS.
Cancer cell proliferative activities were markedly accelerated in s-ESC cases with cancer invasion beyond the muscularis mucosae and lymph nodal involvement, which was associated with a poorer prognosis of the SM-carcinoma compared with the M-carcinoma, and must be one of the important indices to decide the indication of local resection for s-ESC.