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Acceleration of an aminolysis reaction using a PAMAM dendrimer with 64 terminal amine groups

โœ Scribed by Ian K Martin; Lance J Twyman

Book ID
104211697
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
587 KB
Volume
42
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

When compared to an equivalent amine concentration (N-acetylethylene diamine, 64 equivalents), the initial rate of a simple deacylation reaction in water was found to be greatly enhanced when using a PAMAM dendrimer with 64 terminal amine groups. This increase in initial rate is largely due to the hydrophobic binding of the substrate within the outer region of the dendrimer. As a consequence of this binding, the substrate is held in close proximity to the reactive amine groups on the surface of the dendrimer. It is this increase in effective molarity that results in an increase in the observed initial rate.

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โœ John L. Burnett; Amy S.H. King; Ian K. Martin; Lance J. Twyman ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 82 KB

When compared to an equivalent amine concentration of ethylenediamine, the initial rate of a simple aminolysis reaction in water (at pH 8.5) was found to be greatly enhanced by the use of amine terminated PAMAM dendrimers of generations 1-5 (with 4, 8, 16, 32 and 64 terminal amines, respectively). T