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Accelerated growth of syngeneic tumors in mice treated with methylcholanthrene

✍ Scribed by Patsy H. Lill; J. Milburn Jessup; Margaret L. Kripke

Publisher: John Wiley and Sons
Year: 1978
Tongue: French
Weight: 435 KB
Volume: 21
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910210418

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

BALB/c and C3H‐ mice were given a single injection of methylcholanthrene (MCA) and were tested at various times thereafter for immunologic reactivity and resistance to syngeneic tumor challenge. MCA treatment did not affect the rejection of H‐2‐incompatible tumor allografts, the rejection of H‐2‐compatible skin allografts, or the induction of delayed hypersensitivity to DNCB as measured by footpad challenge. In contrast, mice treated with MCA exhibited an increased susceptibility to challenge with several syngeneic ultraviolet‐induced and MCA‐induced fibrosarcomas. These studies demonstrate that in the autochthonous host the measurement of host immune status by in vivo cell‐mediated immune responses to exogenous antigens does not necessarily predict the host response to tumor growth.

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