Accelerated diabetes in non-obese diabetic (NOD) mice differing in incidence of spontaneous disease
โ Scribed by A. G. BAXTER; T. E. MANDEL
- Book ID
- 108698305
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 505 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0009-9104
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Non-obese diabetic mice were treated daily with a mixture of gangliosides from day 30 until day 250 of life or until the mice became diabetic. Ganglioside treatment reduced diabetes incidence from 80-90% to 47% and from 20-30% to zero in female and male mice respectively. Gangliosides did not affect
To investigate the role of glucagon in the development of diabetes mellitus, spontaneously diabetic non-obese mice were studied before (group 1) and after the onset of diabetes mellitus (group 2). In group 1, fasting blood glucose and insulin in plasma and pancreas did not differ significantly, whil