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Accelerated apoptosis and low Bcl-2 expression associated with neuroendocrine differentiation predict shortened survival in operated large cell carcinoma of the lung

✍ Scribed by Anna-Kaisa Eerola; Henni Ruokolainen; Ylermi Soini; Hannu Raunio; Paavo PÄÄKKÖ

Book ID
111723878
Publisher
Springer Netherlands
Year
1999
Tongue
English
Weight
149 KB
Volume
5
Category
Article
ISSN
1219-4956

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CD40 is a cell surface receptor which, when ligated, modulates apoptosis in some cell types, perhaps via activation of the expression of members of the Bcl2 gene family. This study sought to determine whether expression of CD40 in a series of 134 squamous cell carcinomas (SCCs) of the lung was relat