Acanthosis Nigricans and the sign of leser-trélat associated with adenocarcinoma of the gallbladder

✍ Scribed by Michael I. Jacobs; Darrell S. Rigel

• Publisher: John Wiley and Sons
• Year: 1981
• Tongue: English
• Weight: 530 KB
• Volume: 48
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19810715)48:2<325::aid-cncr2820480218>3.0.co;2-9

✦ Synopsis

A case of adenocarcinoma of the gallbladder associated with acanthosis nigricans and the sign of Leser-Trelat is presented. The significant underrepresentation of adenocarcinoma of the gallbladder in association with malignant acanthosis nigricans is noted. If malignant acanthosis nigricans is caused by an ectopic peptide, a relative lack of production of the postulated substance by gallbladder adenocarcinoma cells could account for this finding.