## Abstract Certain aminotetralins are known to be potent dopamine D~2~ receptor agonists. N‐0923, [‐]2‐(N‐propyl‐N‐2‐thienylethylamino)‐5‐hydroxytetralin HCl, recognizes the high and low affinity states of the D~2~ receptor in membranes from bovine caudate with a K~low~ of 79 nM. The selectivity r
ABT-431, a D1 receptor agonist prodrug, has efficacy in Parkinson's disease
✍ Scribed by O. Rascol; O. Blin; C. Thalamas; S. Descombes; C. Soubrouillard; P. Azulay; N. Fabre; F. Viallet; K. Lafnitzegger; S. Wright; J. H. Carter; J. G. Nutt
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 163 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract N‐0923 is a non‐ergot, dopaminergic D~2~ agonist designed to be transdermally available. It has anti‐parkinsonian effects when infused intravenously. An adhesive matrix patch was developed to deliver N‐0923 transdermally (N‐0923 TDS). In this phase II trial, we evaluated the effectiven
1-aminomethyl-5,6-dihydroxy-3-phenylisochroman; NMDA antagonist; CPP; 3-((6)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid
## Abstract 4‐‐Propyl‐9‐hydroxynaphthoxazine, or MK‐458 (HPMC), a selective, nonergot D2 agonist administered orally twice a day in sustained‐release form, was studied as adjunctive therapy with carbidopa‐levodopa (Sinemet) in 12 Parkinson's disease patients with motor response fluctuations. The do