𝔖 Bobbio Scriptorium
✦   LIBER   ✦

ABT-431, a D1 receptor agonist prodrug, has efficacy in Parkinson's disease

✍ Scribed by O. Rascol; O. Blin; C. Thalamas; S. Descombes; C. Soubrouillard; P. Azulay; N. Fabre; F. Viallet; K. Lafnitzegger; S. Wright; J. H. Carter; J. G. Nutt


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
163 KB
Volume
45
Category
Article
ISSN
0364-5134

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


N-0923, a selective dopamine D2 receptor
✍ Dr. J. D. Belluzzi; E. F. Domino; J. M. May; K. S. Bankiewicz; D. A. McAfee 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 800 KB

## Abstract Certain aminotetralins are known to be potent dopamine D~2~ receptor agonists. N‐0923, [‐]2‐(N‐propyl‐N‐2‐thienylethylamino)‐5‐hydroxytetralin HCl, recognizes the high and low affinity states of the D~2~ receptor in membranes from bovine caudate with a K~low~ of 79 nM. The selectivity r

Transdermal dopaminergic D2 receptor ago
✍ J. Thomas Hutton; Leo Verhagen Metman; Thomas N. Chase; Jorge L. Juncos; William 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 35 KB 👁 1 views

## Abstract N‐0923 is a non‐ergot, dopaminergic D~2~ agonist designed to be transdermally available. It has anti‐parkinsonian effects when infused intravenously. An adhesive matrix patch was developed to deliver N‐0923 transdermally (N‐0923 TDS). In this phase II trial, we evaluated the effectiven

Sustained-release (+)-PHNO [MK-458 (HPMC
✍ Dr. Jesse M. Cedarbaum; Mary Clark; Linda H. Toy; Alison Green-Parsons 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 683 KB

## Abstract 4‐‐Propyl‐9‐hydroxynaphthoxazine, or MK‐458 (HPMC), a selective, nonergot D2 agonist administered orally twice a day in sustained‐release form, was studied as adjunctive therapy with carbidopa‐levodopa (Sinemet) in 12 Parkinson's disease patients with motor response fluctuations. The do