✦ LIBER ✦

Abstracts From the American Society for Apheresis 27th Annual Meeting, May 23-26, 2006 Las Vegas, Nevada

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 501 KB
Volume: 21
Category: Article
ISSN: 0733-2459
DOI: 10.1002/jca.20098

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✦ Synopsis

blocked by preincubation with normal human or mouse plasma, but much less so by plasma from TTP patients or ADAMTS13 knockout mice. We further demonstrated that we can completely inhibit mouse ADAMTS13 by injecting group I antibodies into the internal jugular vein of mice. Conclusions: Our results show that at least some TTP patients have a genetically-restricted immune response. This feature, if shared with other TTP patients, suggests a potential therapeutic target for treatment of TTP, e.g. selective deletion of B-cells utilizing the VH1-69 heavy chain gene. Furthermore, the mouse model of acquired ADAMTS13 deficiency will be useful for determining the role of autoantibodies in the pathogenesis of TTP and for the development of novel therapeutic approaches.

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