Abstract of the in vivo synthesis of labile methyl groups : S. Jonsson and W.A. Mosher (J. Am. Chem. Soc., 72, 3316 (1950))
- Book ID
- 103076154
- Publisher
- Elsevier Science
- Year
- 1950
- Tongue
- English
- Weight
- 58 KB
- Volume
- 250
- Category
- Article
- ISSN
- 0016-0032
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✦ Synopsis
Protection of Mice against X-Radiation by Thiourea.--G. LIMPEROS AND W. A. MOSHER (Science, 112, 86 (1950)). Thiourea, injected intraperitoneally (2140 mg./kg.) immediately before X-radiation or given in the drinking water (1%) for a period of six days before X-radiation with 600 r, significantly reduced the mortality of X-rayed mice. Of the control mice, 68% survived, whereas 86% of the mice given thiourea in their drinking water survived. The survival rate of the mice injected with thiourea before irradiation was 35.2%, for the mice injected after irradiation, 7%, and for the controls, 2%. It is believed that the protective effect of thiourea is due to the protection afforded to vital cellular constituents such as nucleic acid, cysteine, glutathione, and sulfhydryl-containing enzymes.