✦ LIBER ✦

Absorption of apomorphine by various routes in parkinsonism

✍ Scribed by Dr. Stephen T. Gancher; John G. Nutt; William R. Woodward

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 361 KB
Volume: 6
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.870060304

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✦ Synopsis

We wanted to determine the absorption and clinical effect of sublingual (SL) and transdermal apomorphine in parkinsonism. Patients received single SL apomorphine doses (N = 7) and the absorption was compared with parenteral (N = 5) and oral (N = 4) doses. One patient received a transdermal dose of apomorphine. The relative bioavailability of SL apomorphine ranged from 10 to 22% of a parenteral apomorphine dose. Oral apomorphine was less than 4% bioavailable, and the transdermal dose did not produce detectable plasma levels. Three patients with motor fluctuations responded to SL apomorphine, with a latency to effect of 20-40 min and a duration of effect of 15-100 min. One patient used SL apomorphine as an adjunct with levodopa, and during 1 month reported a large decrease in "off" periods. We conclude that apomorphine is effectively absorbed by the sublingual route.

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