Absorption of a pharmacological dose of vitamin D3 from two different lipid vehicles in man: Comparison of peanut oil and a medium chain triglyceride
✍ Scribed by Inger Holmberg; Lage Aksnes; Tomas Berlin; Bengt Lindbäck; Justine Zemgals; Björn Lindeke
- Book ID
- 101702398
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 462 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0142-2782
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✦ Synopsis
Abstract
The absorption of a pharmacological dose of vitamin D~3~ from two different lipid vehicles, peanut oil, containing long chain fatty acids, and a medium chain triglyceride was compared. Serial measurements of the serum concentration of vitamin D~3~ after dosage were made. The serum levels of 25‐hydroxyvitamin D~3~, the major circulating vitamin D~3~ metabolite, were also determined. The analytical methods used were based on HPLC. In the fasting state, the serum levels of vitamin D~3~ were significantly higher after administration in peanut oil than after administration in the medium chain triglyceride. When the vitamin D~3~ dose was ingested together with food no difference between the two formulations was observed. Only small inter‐formulation differences in serum 25‐hydroxyvitamin D~3~ levels were detected. The results indicate that the presence of long chain fatty acids facilitates the absorption of vitamin D~3~.