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Absorption, metabolism, and excretion of14C-labeled Tapentadol HCl in healthy male subjects

✍ Scribed by Rolf Terlinden; Joachim Ossig; Frank Fliegert; Claudia Lange; Karin Göhler

Publisher
Springer-Verlag
Year
2007
Tongue
English
Weight
711 KB
Volume
32
Category
Article
ISSN
0378-7966

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Aclidinium bromide is a novel, inhaled long-acting muscarinic antagonist with low systemic activity developed for the treatment of COPD. It is an ester compound rapidly hydrolysed in plasma into inactive alcohol and acid metabolites. In this Phase I, open-label study, the rates and routes of elimina