Absorption kinetics of topical clindamycin preparations

✍ Scribed by Mark G. Eller; Randal L. B. Smith; J. Paul Phillips

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 375 KB
• Volume: 10
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510100508

✦ Synopsis

Systemic clindamycin absorption was examined in 12 male Caucasians without acne who recieved 1 ml of Cleocin-T@ and 1 ml of 1 per cent clindamycin HC1 in Vehicle-N@ (Neutrogena) applied topically the face every 12 h for 4 days according to a crossover design. In a separate phase clindamycin phosphate was administered by a n IV infusion of 300 mg over 10 min. Systemic absorption was much higher with clindamycin in Vehicle-N than with Cleocin-T. Absolute bioavailability calculated from cumulative urinary excretion and serum AUCs were in good agreement and averaged 1.7 per cent and 7.5 per cent for Cleocin-T and clindamycin in Vehicle-N, respectively. Peak serum concentrations ranged from less than 0.5 ng ml-1 to 6ng ml-' for Cleocin-T and from 4-20ng ml-' for clindamycin in Vehicle-N. Absorption profiles indicated zero order absorption with Cleocin-T. No appreciable systemic accumulation from the repeated topical applications was noted. Systemic exposure to clindamycin from these formulations is minimal.