Absorption and disposition of ibuprofen in the elderly

✍ Scribed by David J. Greenblatt; Darrell R. Abernethy; Rita Matlis; Jerold S. Harmatz; Richard I. Shader

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 277 KB
• Volume: 27
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780270918

✦ Synopsis

Ibuprofen is a nonsteroidal antiinflammatory agent extensively used in the treatment of pain and inflammatory disorders (1). Most pharmacokinetic studies of ibuprofen have involved healthy young male volunteers (2-6). However, patients who use ibuprofen for clinical purposes are often elderly and many are women. Previous studies have documented alterations in drug disposition associated with the aging process (7). The present study assesses the effects of age and sex and the pharmacokinetics of single doses of ibu-'profen in healthy volunteers.

SUBJECTS AND METHODS

Subjects. Thirty-seven healthy male and female volunteers, aged 20-88 years, participated after giving written informed consent. They were divided into 4 cohorts: young male, young female, elderly male, and elderly female (Table I). Young volunteers ranged in age from 20-44 and were healthy, active, ambulatory adults with no evidence of medical disease and taking From the