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Absolute quantification and modulation of cytochrome P450 3A isoforms in cattle liver

โœ Scribed by Zancanella, V.; Giantin, M.; Dacasto, M.

Book ID
127009892
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
454 KB
Volume
202
Category
Article
ISSN
1090-0233

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Simultaneous absolute quantification of
Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with In silico target peptide selection
โœ Hirotaka Kawakami; Sumio Ohtsuki; Junichi Kamiie; Takashi Suzuki; Takaaki Abe; T ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 162 KB

Cytochrome P450 (CYP) proteins are involved in the biological oxidation and reduction of xenobiotics, affecting the pharmacological efficiency of drugs. This study aimed to establish a method to simultaneously quantify 11 CYP isoforms by multiplexed-multiple reaction monitoring analysis with liquid