Absolute configuration of norzoanthamine, a promising candidate for an osteoporotic drug
β Scribed by Makoto Kuramoto; Koji Hayashi; Yasuyuki Fujitani; Kohji Yamaguchi; Tomoko Tsuji; Kaoru Yamada; Yasuharu Ijuin; Daisuke Uemura
- Book ID
- 104257592
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 217 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
The absolute configuration of norzoanthamine (1) was determined to be 2R, 4S, 6S, 9S, 10R, 12S, 13R, 18S, 21S, and 22S based on tH NMR spectral data of the MTPA esters of norzoanthamine derivatives. The possible biogenesis of zoanthamines is also proposed.
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## Abstract Poly(ADPβribose) polymerases are involved in many aspects of regulation of cellular functions. Using NAD^+^ as a substrate, they catalyse the covalent transfer of ADPβribose units onto several acceptor proteins to form a branched ADPβribose polymer. The best characterised and first disc