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Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanistic in vitro-in vivo extrapolation of oral drug absorption

โœ Scribed by Harwood, M. D.; Neuhoff, S.; Carlson, G. L.; Warhurst, G.; Rostami-Hodjegan, A.


Book ID
118753202
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
984 KB
Volume
34
Category
Article
ISSN
0142-2782

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The intestinal efflux pump, P-glycoprotein (P-gp), located in the apical membranes of intestinal absorptive cells, can reduce the bioavailability of a wide range of drugs which are substrates for this membrane transporter. In addition to anticancer and anti-HIV drugs, NCEs for other disease indicati