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Absence ofp15INK4Bandp16INK4AGene Alterations in Primary Cervical Carcinoma Tissues and Cell Lines with Human Papillomavirus Infection

✍ Scribed by Jin Woo Kim; Sung Eun Namkoong; Soon Won Ryu; Ho Shik Kim; Jin Woong Shin; Joon Mo Lee; Dae Hoon Kim; In Kyung Kim

Book ID
112247403
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
197 KB
Volume
70
Category
Article
ISSN
0090-8258

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## Background: D-type cyclins, in association with the cyclin-dependent kinases cdk4 and cdk6, promote progression through the g1 phase of the cell cycle. cdk activity is modulated by inhibitors such as p15ink4b and p16ink4a. loss of function of p15ink4b and p16ink4a (multiple tumor suppressor-i an