Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric mice
β Scribed by Nobuhiko Hiraga; Michio Imamura; Tsuyoshi Hatakeyama; Shosuke Kitamura; Fukiko Mitsui; Shinji Tanaka; Masataka Tsuge; Shoichi Takahashi; Hiromi Abe; Toshiro Maekawa; Hidenori Ochi; Chise Tateno; Katsutoshi Yoshizato; Takaji Wakita; Kazuaki Chayama
- Book ID
- 116652008
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 613 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0168-8278
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The aim of the study was to assess the role of different viral strains of hepatitis C virus (HCV) in determining the outcome of the alpha-interferon (IFN) therapy. Fifty-seven patients (34 from Italy and 23 from Japan) with HCV-positive liver disease were enrolled in the study. The NS4 region of HCV
Amino acid (aa) substitutions of core 70 and 91 and in the NS5A (nonstructural protein 5A) interferon sensitivity determining region (ISDR) as well as genetic polymorphisms in the host interleukin-28B (IL28B) locus affect the outcome of interferon (IFN)-based therapies for patients with chronic hepa