Absence of transcallosal inhibition in adolescents with diplegic cerebral palsy

✍ Scribed by Florian Heinen; Janbernd Kirschner; Urban Fietzek; Franz-Xaver Glocker; Volker Mall; Rudolf Korinthenberg

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 86 KB
• Volume: 22
• Category: Article
• ISSN: 0148-639X
• DOI: 10.1002/(sici)1097-4598(199902)22:2<255::aid-mus14>3.0.co;2-7

✦ Synopsis

The role of intracortical organization in the pathophysiology of cerebral palsy (CP) is not clear. We used transcranial magnetic stimulation to investigate the paradigm of transcallosal inhibition (TI) in a group of adolescent patients with diplegic CP (n = 4), hereditary spastic paraplegia (n = 2), and healthy control adolescents (n = 4). None of the patients with CP showed TI, whereas all other subjects had normal TI. These findings indicate a lack of inhibitory control of the motor cortex in CP.