Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide
β Scribed by van Nifterik, K A; van den Berg, J; van der Meide, W F; Ameziane, N; Wedekind, L E; Steenbergen, R D M; Leenstra, S; Lafleur, M V M; Slotman, B J; Stalpers, L J A
- Book ID
- 110000503
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 413 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0007-0920
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## Abstract Epigenetic silencing of the O^6^βmethylguanineβDNA methyltransferase (__MGMT__) gene promoter is associated with prolonged survival in glioblastoma patients treated with temozolomide (TMZ). We investigated whether glioblastoma recurrence is associated with changes in the promoter methyl