Absence of ras gene mutations in UV-induced malignant melanomas correlates with a dermal origin of melanocytes in Monodelphis domestica

Characterization of the CDKN2A and ARF g

Characterization of the CDKN2A and ARF genes in UV-induced melanocytic hyperplasias and melanomas of an opossum (Monodelphis domestica)

✍ Jeannie Chan; Edward S. Robinson; Julia Atencio; Zhiqiang Wang; Steven Kazianis; 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 181 KB

## Abstract We examined the involvement of the cyclin‐dependent kinase inhibitor 2A (__CDKN2A__) locus in the pathogenesis of ultraviolet (UV) radiation–induced melanomas in an opossum (__Monodelphis domestica__) melanoma model in which suckling young were exposed to UVB to produce melanocytic lesi