Of 40 Wilms tumors with chromosome abnormalities, 6 were hypodiploid, 10 were pseudodiploid, 7 were hyperdiploid with 47 to 49 chromosomes, and 17 were hyperdiploid with 50 or more chromosomes, mostly including Ο©12. WT1 deletions/ mutations were found in one hypodiploid, eight pseudodiploid, and one
Absence of PPP2R1A mutations in Wilms tumor
β Scribed by Ruteshouser, E Cristy; Ashworth, Linda K; Huff, Vicki
- Book ID
- 110064591
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 119 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0950-9232
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We conducted a comparative study of the prevalence of gerrnline WTI mutations in patients with Wilms' tumor. Patients in Group l have familial Wilms' tumor, bilateral disease, associated urogenital anomalies, and/or second cancers. Those in Group 2 are unilateral, sporadic Wilrns' patients without o
## Abstract The Wilms' tumor 1 gene, __WT1__, encodes a zincβfinger protein that is implicated in the development of Wilms' tumor. Mutant or aberrantly expressed WT1 isoforms have also been described in desmoplastic small round cell tumor, acute leukemias, mesothelioma, breast tumors and melanoma.