Cellular senescence induced by p53-ras c
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Maria E. Castro; Maria del Valle Guijarro; Victoria Moneo; Amancio Carnero
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Article
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2004
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John Wiley and Sons
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English
⚖ 300 KB
## Abstract Oncogenic activation in primary murine fibroblasts initiates a senescence‐like cell cycle arrest that depends on the p53 tumor suppressor pathway. Conditional p53 activation efficiently induced a reversible cell cycle arrest but was unable to induce features of senescence. In contrast,