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Absence of p21WAF1 cooperates with c-myc in bypassing Ras-induced senescence and enhances oncogenic cooperation

✍ Scribed by Carnero, Amancio; Beach, David H


Book ID
110068907
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
163 KB
Volume
23
Category
Article
ISSN
0950-9232

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## Abstract Oncogenic activation in primary murine fibroblasts initiates a senescence‐like cell cycle arrest that depends on the p53 tumor suppressor pathway. Conditional p53 activation efficiently induced a reversible cell cycle arrest but was unable to induce features of senescence. In contrast,