Absence of NOTCH1 gene mutations in MALT lymphomas
โ Scribed by Afua Adjeiwaa Mensah; Andrea Rinaldi; Maurilio Ponzoni; Vincenzo Canzonieri; Silvia Uccella; Davide Rossi; Govind Bhagat; Gianluca Gaidano; Emanuele Zucca; Francesco Bertoni
- Book ID
- 114714596
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 68 KB
- Volume
- 157
- Category
- Article
- ISSN
- 0007-1048
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Twenty-seven lymphomas of mucosa-associated lymphoid tissue (MALT) derived from distinct anatomical sites were tested for the presence of genetic lesions commonly involved in B-cell lymphomagenesis, including activation of proto-oncogenes (BCL-1, BCL-2, BCL-6, and c-MYC), disruption of tumor suppres
c-myc gene abnormalities associated with lymphomagenesis, including rearrangements and mutations in the regulatory region between exon I and intron I, have been studied in 54 MALT lymphomas (43 low and 11 high grade) and 36 nodal lymphomas (27 low and 9 high grade). By Southern blot analysis, none o