Subacute sclerosing panencephalitis, a rare, progressive, fatal central nervous system disease of children, is caused by measles virus. Clinical signs occur months to several years after recovery from acute measles infection. It is not known where the virus persists while the disease is inapparent.
Absence of measles virus receptor (CD46) in lesions of subacute sclerosing panencephalitis brains
✍ Scribed by Akihiko Ogata; Stefanie Czub; Seiko Ogata; S. Louise Cosby; Stephen McQuaid; Herbert Budka; Volker ter Meulen; Jürgen Schneider-Schaulies
- Publisher
- Springer-Verlag
- Year
- 1997
- Tongue
- English
- Weight
- 351 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0001-6322
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Significantly higher CSF titers of hemagglutination (HI) measles virus antibody were found in 22 patients with subacute sclerosing panencephalitis (SSPE) and more elevated titers of measles virus neutralization (NV) antibody were encountered in 19 patients with SSPE than in 50 children and young adu
Using the method of haemagglutination inhibition, the authors determined the levels of measles antibodies in the saliva of 14 children with subacute sclerosing panencephalitis. In 13 of them these antibodies were found in titres from 1:8 to 1:128. In the control groups, comprising 29 children, these
A cytopathic measles virus was isolated from a brain biopsy of a subacute sclerosing panencephalitis (SSPE) patient. The agent could be transferred to Vero cells by cocultivation, but the infectivity always remained cell-associated -ie, a defective virus infection. The cell-associated nature of the