Absence of linkage to the ataxia telangiectasia locus in familial breast cancer
✍ Scribed by Richard Wooster; Deborah Ford; Jonathan Mangion; Bruce A. J. Ponder; Julian Peto; Douglas F. Easton; Michael R-Stratton
- Book ID
- 104668448
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 435 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0340-6717
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## Abstract Ataxia‐telangiectasia (AT) is a rare autosomal recessive disorder, characterized by progressive neuronal degeneration, immunological deficiency, radio‐sensitivity and an increased risk of cancer. Although several studies have confirmed that AT heterozygosis increases the risk of breast
## Abstract Epidemiological studies have indicated that ataxia‐telangiectasia (AT) heterozygotes in AT families have an increased risk of cancer, particularly of breast cancer (BC). However, in BC case–control studies, no significant differences were found in the frequency of __ATM__ mutations betw
## Abstract Fifteen pedigrees with a total of 75 cases of breast cancer, 10 of ovarian cancer and 53 of other cancers have been collected. Polymorphic markers on chromosome 17q have been screened to locate a putative breast‐cancer gene using DNA from relevant individuals within these families. Pair