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Absence of integrin α6 leads to epidermolysis bullosa and neonatal death in mice

✍ Scribed by Georges-Labouesse, Elisabeth; Messaddeq, Nadia; Yehia, Ghassan; Cadalbert, Laurence; Dierich, Andrée; Le Meur, Marianne

Book ID
109916506
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
699 KB
Volume
13
Category
Article
ISSN
1061-4036

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## Abstract Mice lacking the α6 integrin chain die at birth with severe skin blistering. To further study the function of α6 integrin in skin, we generated conditionally immortalized cell lines from the epidermis of wild‐type and α6 deficient mouse embryos. Mutant cells presented a decreased adhesi