✦ LIBER ✦

Absence of growth-hormone receptor in hepatocellular carcinoma and cirrhotic liver

✍ Scribed by Tien-Chun Chang; Jyh-Jian Lin; Shan-Chang Yu; Tien-Jye Chang

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 404 KB
Volume: 11
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840110121

No coin nor oath required. For personal study only.

✦ Synopsis

Republic of China

Hepatocellular carcinoma is a hormone-sensitive tumor. It has been reported that thyroxine and prolactin significantly stimulated hepatoma growth, whereas growth hormone failed to do so. To learn whether the growth hormone receptor is present in human hepatocellular carcinoma, we used radioreceptor assays in samples of human hepatocellular carcinoma. The liver tissues adjacent to hepatocellular carcinoma (mostly cirrhotic) and control liver tissues (taken during various surgical procedures) were also studied. The study results showed that the affinity constant and capacity of high-affinity growth hormone receptor in normal liver tissueswere6.6 k 2.0 x 101Omol/L-l(mean k SE,n = 7) and 20.7 k 11.5 fmol/mg protein, respectively. The affinity constant and capacity of low-affinity growth hormone receptor in normal liver tissues were 8.9 f 3.3 x los mol/L-' and 64.7 k 32.1 fmollmg protein, respectively. The absence of growth hormone receptor in human hepatocellular carcinoma and cirrhotic liver samples may explain the absence of growth hormone in the stimulation of hepatoma growth and the decrease of somatomedin levels in cirrhosis. (HEPATOLOGY 1990;

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