Absence of changes in the number of synovial sublining macrophages after ineffective treatment for rheumatoid arthritis: Implications for use of synovial sublining macrophages as a biomarker

Folate receptor β as a potential deliver

Folate receptor β as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients

✍ Joost W. Van Der Heijden; Ruud Oerlemans; Ben A. C. Dijkmans; Huiling Qi; Conny 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 220 KB

## Abstract ## Objective To determine the expression of folate receptor β (FRβ) in synovial biopsy tissues and peripheral blood lymphocytes from rheumatoid arthritis (RA) patients and to identify novel folate antagonists that are more selective in the targeting and internalization of FRβ than meth