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Absence of cardiotoxicity of the experimental cytotoxic drug cyclopentenyl cytosine (CPEC) in rats

✍ Scribed by Kirsten Schimmel; Roel Bennink; Kora de Bruin; Rene Leen; Karsten Sand; Maurice van den Hoff; André van Kuilenburg; Jean-Luc Vanderheyden; Neil Steinmetz; Martin Pfaffendorf; Arnauld Verschuur; Henk-Jan Guchelaar

Book ID
105870311
Publisher
Springer-Verlag
Year
2005
Tongue
English
Weight
451 KB
Volume
79
Category
Article
ISSN
0340-5761

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Quantitative analysis of the experimenta
Quantitative analysis of the experimental cytotoxic drug cyclopentenyl cytosine and its metabolite in plasma with HPLC tandem mass spectrometry
✍ Kirsten Schimmel; Henk van Lenthe; Rene Leen; Willem Kulik; Arnauld Verschuur; H 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 140 KB

## Abstract The cytotoxic drug cyclopentenyl cytosine (CPEC) is currently being investigated in early clinical trials. Monitoring of plasma levels is required for pharmacokinetic analysis and management of toxicity. This paper describes the analysis of CPEC and cyclopentenyl uracil (CPEU) in plasma