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Absence of association with cancer risk and low frequency of alterations at a p53 responsive PIG3 gene polymorphism in breast and lung carcinomas

✍ Scribed by V.G. Gorgoulis; T. Liloglou; F. Sigala; D. Korkolis; D. Yannoukakos; E. Papalambros; P.J. Asimacopoulos; A.G. Papavassiliou; A. Kotsinas


Book ID
113808470
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
130 KB
Volume
556
Category
Article
ISSN
0027-5107

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## Abstract Lung cancer is the leading cause of cancer mortality in the world. Although exposure to carcinogens is considered to be the main cause, genetic variation may contribute to lung cancer risk. Murine double minute 2, MDM2, is a key regulator of p53 activity and recently a polymorphism in t