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Abrogation of the in vitro generation of the cytotoxic T-cell response to a murine tumor: The role of suppressor cells

✍ Scribed by Dr. Philip Frost; Pamela Prete; Robert Kerbel

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
723 KB
Volume
30
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

A reproducible in vitro assay for the effect of suppressor T cells on the generation of an in vitro cytotoxic response to a metastatic murine tumor is described. Suppression in this system is maximal. The model uses splenic T cells from DBA/2 mice bearing the MDAY‐D2 metastatic tumor as suppressors of the in vitro generation of a cell mediated cytotoxic response by syngeneic tumor‐bearer (i.e., primed) peripheral lymph node cells stimulated with mitomycin C‐treated MDAY‐D2 tumor cells. The effect of the cell mediated cytotoxic response is profound, specific and mediated by splenic T cells. The suppressor T cells appear to impair precursor rather than mature cytotoxic cells. A highly immunogenic variant of MDAY‐D2, namely MDWI, does not generate a suppressor response. Suppressor T cells from an MDAY‐D2 tumor‐bearer cannot suppress the in vitro response to MDWI. This model of potent suppressor T‐cell action is highly reproducible and offers an opportunity for the analysis of why some tumors generate an effective cell mediated cytotoxic response which others stimulate dramatic suppressor T‐cell response.

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