## Abstract The Raf serine‐threonine kinase is upregulated in many human tumors and plays a pivotal role in tumor cell proliferation and survival. Abrogation of c‐Raf expression by specific antisense oligonucleotides (Raf‐AS‐ODN) efficiently blocks tumor cell growth and induces apoptosis in human c
✦ LIBER ✦
Abrogation of c-Raf expression induces apoptosis in tumor cells
✍ Scribed by Lau, Quek Choon; Brüsselbach, Sabine; Müller, Rolf
- Book ID
- 110061244
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 633 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0950-9232
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We previously reported that messenger RNA expression of DENN (differentially expressed in normal and neoplastic cells) is considerably higher in cancer cell lines than in normal cells. In our present study, we established that certain cancer cell lines express conspicuously higher levels of the 2 DE