Abolition of the cyclic variations in radiosensitivity during meiosis in a sporulation mutant blocked in premeiotic DNA synthesis

✍ Scribed by Hottinguer-De Margerie, H. ;Moustacchi, E.

• Publisher: Springer
• Year: 1979
• Tongue: English
• Weight: 560 KB
• Volume: 175
• Category: Article
• ISSN: 0026-8925
• DOI: 10.1007/bf00397225

✦ Synopsis

The response to ultraviolet light (254 nm) of two sporulation mutants during the meiotic process was compared to that of a wild type diploid strain of Saccharomyces cerevisiae. The cyclic pattern for cell killing and rhoinduction characteristic of diploid wild type cells persists in a strain able to perform the premeiotic DNA synthesis but which is blocked in the further steps of meiosis (spo8 DMS1). On the contrary, these fluctations are abolished in a derived mutant (spo8 dsml) which is blocked in the premeiotic DNA synthesis. Under these conditions, the response to cell killing can be dissociated from that observed for rho induction.