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Abnormalities in Oligodendrocyte Subpopulations in the md Rat Partial Recovery of Maturation in Vitro

โœ Scribed by A. ESPINOSA DE LOS MONTEROS; M. ZHANG; M. N. GORDON; S. KUMAR; S. SCULLY; J. de VELLIS

Book ID
119865274
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
141 KB
Volume
605
Category
Article
ISSN
0890-6564

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A point mutation in exon 3 of the proteolipid protein (PLP) gene of the myelin-deficient (md) rat leads to a failure of oligodendrocyte maturation and early death of oligodendrocytes, resulting in dysmyelination. It has been suggested that an alternative-splice isoform of PLP, known as DM-20, might