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Abnormalities in cellular adhesion of neuroblastoma and fibroblast models of Lesch Nyhan syndrome

✍ Scribed by N.C Stacey; M.H.Y Ma; J.A Duley; G.P Connolly

Book ID
117489706
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
89 KB
Volume
98
Category
Article
ISSN
0306-4522

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## Abstract Extracellular purines have essential roles in neuronal development; hence, disruptions in their metabolism as reported in Lesch Nyhan syndrome (LNS) could result in developmental abnormalities. The deficiency of hypoxanthine‐guanine phosphoribosyl transferase (HGPRT) in LNS leads to inc