Abnormal Transsulfuration and Glutathione Metabolism in the Micropig Model of Alcoholic Liver Disease
β Scribed by Jesus A. Villanueva; Farah Esfandiari; Donna H. Wong; Iram Ahmad; Stepan Melnyk; S. Jill James; Charles H. Halsted
- Book ID
- 109123543
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 176 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0145-6008
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The pathogenesis of alcohol-induced liver disease involves the adverse effects of ethanol metabolites and oxidative tissue injury. Previous studies indicated that covalent protein adducts with reactive aldehydes may be formed in alcohol consumers. To study the role of such protein adducts in the dev
Long-term ethanol feeding has been shown to selectively reduce hepatic mitochondrial glutathione content by impairing mitochondrial uptake of this thiol. In this study, we assessed the role of this defect in evolution of alcoholic liver disease by examining the mitochondrial glutathione pool and lip
A 27-yr-old Caucasian female dental assistant presented with fatigue, malaise, and nausea, and physical findings of jaundice and hepatomegaly. Total bilirubin was 20.3 mg/dL (direct: 14.6 mg/dL), serum albumin 2.5 gm/dL, aspartate aminotransferase 230 U/L, alanine aminotransferase 58 U/L, alkaline p