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Abnormal timing in the prenatal ossification of vertebral column and hand in Crouzon syndrome

✍ Scribed by Kj�r, Inger; Fischer Hansen, Birgit; Kj�r, Klaus W.; Skovby, Flemming

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 24 KB
Volume: 90
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(20000228)90:5<386::aid-ajmg8>3.0.co;2-m

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✦ Synopsis

We report on a radiographically examined fetus (gestational age 13 weeks) with Crouzon syndrome caused by a mutation in the gene encoding the fibroblast growth factor 2 (FGFR2). We found an approximately 2-week delay in vertebral body and hand ossification with normal vertebral arch ossification, suggesting that regionally delayed skeletal maturation might be a manifestation of FGFR2 mutation syndromes. The findings support other studies indicating that different signaling pathways control skeletal maturation in vertebral bodies and vertebral arches.

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