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Abnormal sensorimotor integration is related to disease severity in Parkinson's disease: A TMS study

✍ Scribed by Stefano Tamburin; Antonio Fiaschi; Domenico Idone; Piergiorgio Lochner; Paolo Manganotti; Giampietro Zanette

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
245 KB
Volume
18
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Hyperexcitability of the motor system has been reported in Parkinson's disease (PD). We evaluate how cutaneous afferents modulate motor excitability in PD patients and whether abnormal modulation is correlated to parkinsonian symptoms. Digital stimulation causes abnormal enhancement of motor responses in patients. This effect may be one of the features of motor hyperexcitability in PD. Cutaneomotor hyperexcitability correlates with clinical scores, suggesting that abnormal processing of cutaneous inputs might contribute to the pathogenesis of parkinsonian symptoms. Β© 2003 Movement Disorder Society

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