𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Abnormal regulation of in vitro IgG production in multiple sclerosis

✍ Scribed by Dr. Robert E. Kelley; George W. Ellison; Lawrence W. Myers; Vincent Goymerac; Susan B. Larrick; Carol C. Kelley

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
625 KB
Volume
9
Category
Article
ISSN
0364-5134

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A pokeweed mitogen‐stimulated IgG synthesis assay was used to evaluate T suppressor cell function in peripheral blood lymphocytes (PBL) obtained form multiple sclerosis (MS) patients. Autochthonous cultures of fractionated and recombined MS B and T cells exhibited less suppression of IgG synthesis than similar cultures of PBL from control subjects. No difference occurred in the levels of suppression among MS patients grouped according to disease states. When allogenic cultures of MS B and normal T cells or normal B and MS T cells were compared to autochthonous cultures of control cells, no differences were observed. The results suggest that the lower levels of suppression observed in autologous MS cell cultures are not a result of T suppressor cell dysfunction alone.

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