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Abnormal Regulation of Cyclic AMP Phosphodiesterase: A Hypothesis for the Development of Cancer of Nerve Cells

โœ Scribed by K.N. Prasad


Book ID
115110663
Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
221 KB
Volume
2
Category
Article
ISSN
0301-4681

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โœ Alexander V. Itkes; Kyril T. Turpaev; Olga N. Kartasheva; Constantin A. Kafiam; ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› Springer ๐ŸŒ English โš– 456 KB

Treatment of NIH 3T3 cells with adenylate cyclase activator adrenaline (10(-6) M) or cAMP phosphodiesterase inhibitor theophylline (10(-3) M) was shown to lead to intracellular cAMP elevation followed by a 2.0-to 2.5-fold increase in the 2',5'-oligoadenylate synthetase activity. This process was blo