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Abnormal metabolism of carnitine and valproate in a case of acute encephalopathy during chronic valproate therapy

✍ Scribed by Murakami, Kiyotaka; Sugimoto, Tateo; Nishida, Naoki; Kobayashi, Yohnosuke; Kuhara, Tomiko; Matsumoto, Isamu

Book ID
122618172
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
476 KB
Volume
14
Category
Article
ISSN
0387-7604

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The pharmacokinetics of total and free valproic acid (VPA) in plasma and whole blood was investigated in seven adolescents and young adults (mean age 17.3 years) during a dosage interval at steady state. The concentration curves of VPA in whole blood after an oral morning dose (mean 8.2 mg/kg body w