ABNORMAL GANGLIOSIDE IN NEUROBLASTOMA
โ Scribed by Peak, J.D.; Berry, P.J.; Pennock, C.A.
- Book ID
- 122897219
- Publisher
- The Lancet
- Year
- 1986
- Tongue
- English
- Weight
- 292 KB
- Volume
- 327
- Category
- Article
- ISSN
- 0140-6736
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Substantial concentrations of the cell-surface glycosphingolipid, the disialoganglioside GD2, are uniformly present in human neuroblastoma tumors. This ganglioside can also be detected in the plasma of patients with neuroblastoma by direct thin-layer chromatographic analysis. Among 32 neuroblastoma
Gangliosides are shed in substantial amounts by some tumors, including human neuroblastoma, and these molecules modulate experimental tumor formation in vivo. We now demonstrate that neuroblastoma tumor gangliosides have potent immunoregulatory activity. Gangliosides of every one of 17 tumors studie