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Abnormal Expression of p16INK4a, Cyclin D1, Cyclin-Dependent Kinase 4 and Retinoblastoma Protein in Gastric Carcinomas

✍ Scribed by Ichiro Kishimoto; Hiroyuki Mitomi; Yasuo Ohkura; Hideki Kanazawa; Naoshi Fukui; Masahiko Watanabe


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
380 KB
Volume
98
Category
Article
ISSN
0022-4790

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## Background: D-type cyclins, in association with the cyclin-dependent kinases cdk4 and cdk6, promote progression through the g1 phase of the cell cycle. cdk activity is modulated by inhibitors such as p15ink4b and p16ink4a. loss of function of p15ink4b and p16ink4a (multiple tumor suppressor-i an

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## Background: In the normal cell cycle, tumor suppressor gene products (p53) and cyclin (cyclin d1) cooperate. abnormalities in the cooperation of these factors may result in malignant transformation of the cell. mutant p53 protein overexpression is defined in many human cancers, including endomet