Abnormal chromosome migration and chromosome aberrations in mouse oocytes during meiosis II in the presence of topoisomerase II inhibitor ICRF-193

Application of fluorescence in situ hybr

Application of fluorescence in situ hybridisation to study the relationship between cytotoxicity, chromosome aberrations, and changes in chromosome number after treatment with the topoisomerase II inhibitor amsacrine

✍ Lynnette R. Ferguson; Glenn Whiteside; Karen M. Holdaway; Bruce C. Baguley 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 704 KB

Amsacrine (4'-(9-acridinylamino)methanesulphonm-anisidide) is an antileukemic drug which inhibits topoisomerase I 1 (topo 11) enzymes. We studied effects of two concentrations of amsacrine on the GM101 15A cell line. This is a Chinese hamster line containing a single human chromosome 4, which can be