During B- and T-cell ontogeny, extensive apoptosis occurs at distinct stages of development. Agents that increase intracellular levels of cAMP induce apoptosis in thymocytes and mature B cells, prompting us to investigate the role of cAMP signaling in human CD10+ B-precursor cells. We show for the f
โฆ LIBER โฆ
Abnormal Activity of the MAPK- and cAMP-Associated Signaling Pathways in Frontal Cortical Areas in Postmortem Brain in Schizophrenia
โ Scribed by Funk, Adam J; McCullumsmith, Robert E; Haroutunian, Vahram; Meador-Woodruff, James H
- Book ID
- 126463703
- Publisher
- Nature Publishing Group
- Year
- 2011
- Tongue
- English
- Weight
- 529 KB
- Volume
- 37
- Category
- Article
- ISSN
- 1470-634X
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## Abstract The cannabinoids (CB) modulate the extracellular signalโregulated kinase (ERK), leading to various forms of plasticity in the brain. Little is known, however, on the in vivo shortโ and longโterm activation and regulation of the components of mitogenโactivated protein kinase (MAPK)/ERK s