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Ablation of the metal ion-induced endocytosis of the prion protein by disease-associated mutation of the octarepeat region

✍ Scribed by W.Sumudhu S. Perera; Nigel M. Hooper


Book ID
114318253
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
235 KB
Volume
11
Category
Article
ISSN
0960-9822

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## Abstract We report two Creutzfeldt‐Jakob disease (CJD) patients with rhythmic pupillary and palpebral oscillation who had a mutation of prion protein codon 200 that resulted in the substitution of lysine for glutamate (Glu/Lys). Alternating dilation and constriction of the pupils combined with e